node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cpar_0287 | Cpar_0790 | Cpar_0287 | Cpar_0790 | PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cte:CT1921 cysteine synthase/cystathionine beta-synthase family protein. | KEGG: cte:CT1368 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.458 |
Cpar_0287 | Cpar_1870 | Cpar_0287 | Cpar_1870 | PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cte:CT1921 cysteine synthase/cystathionine beta-synthase family protein. | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | 0.957 |
Cpar_0287 | glyA | Cpar_0287 | Cpar_1518 | PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cte:CT1921 cysteine synthase/cystathionine beta-synthase family protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
Cpar_0686 | Cpar_0790 | Cpar_0686 | Cpar_0790 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | KEGG: cte:CT1368 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.929 |
Cpar_0686 | gcvH | Cpar_0686 | Cpar_0562 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.730 |
Cpar_0686 | gcvPB | Cpar_0686 | Cpar_0121 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.608 |
Cpar_0686 | gcvT | Cpar_0686 | Cpar_0418 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.957 |
Cpar_0686 | glyA | Cpar_0686 | Cpar_1518 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.977 |
Cpar_0686 | purH | Cpar_0686 | Cpar_1716 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: cte:CT0320 phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.966 |
Cpar_0686 | purN | Cpar_0686 | Cpar_1717 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.950 |
Cpar_0790 | Cpar_0287 | Cpar_0790 | Cpar_0287 | KEGG: cte:CT1368 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cte:CT1921 cysteine synthase/cystathionine beta-synthase family protein. | 0.458 |
Cpar_0790 | Cpar_0686 | Cpar_0790 | Cpar_0686 | KEGG: cte:CT1368 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | 0.929 |
Cpar_0790 | gcvH | Cpar_0790 | Cpar_0562 | KEGG: cte:CT1368 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.646 |
Cpar_0790 | gcvT | Cpar_0790 | Cpar_0418 | KEGG: cte:CT1368 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.931 |
Cpar_0790 | glyA | Cpar_0790 | Cpar_1518 | KEGG: cte:CT1368 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
Cpar_1870 | Cpar_0287 | Cpar_1870 | Cpar_0287 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cte:CT1921 cysteine synthase/cystathionine beta-synthase family protein. | 0.957 |
Cpar_1870 | glyA | Cpar_1870 | Cpar_1518 | KEGG: cte:CT0173 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
gcvH | Cpar_0686 | Cpar_0562 | Cpar_0686 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: cte:CT0719 methylenetetrahydrofolate dehydrogenase. | 0.730 |
gcvH | Cpar_0790 | Cpar_0562 | Cpar_0790 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | KEGG: cte:CT1368 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.646 |
gcvH | gcvPA | Cpar_0562 | Cpar_0563 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |