STRINGSTRING
purH protein (Chlorobaculum parvum) - STRING interaction network
"purH" - Bifunctional purine biosynthesis protein PurH in Chlorobaculum parvum
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purHBifunctional purine biosynthesis protein PurH; KEGG- cte-CT0320 phosphoribosylaminoimidazolecarboxamide formyltransferase (523 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (200 aa)
  0.999
purD
KEGG- cte-CT1674 phosphoribosylamine--glycine ligase; TIGRFAM- phosphoribosylamine/glycine ligase; PFAM- phosphoribosylglycinamide synthetase; Belongs to the GARS family (425 aa)
 
 
  0.996
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (440 aa)
   
  0.992
Cpar_1222
TIGRFAM- adenylosuccinate lyase; PFAM- fumarate lyase; KEGG- cte-CT0989 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (434 aa)
   
  0.992
purM
KEGG- cte-CT0094 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM- phosphoribosylformylglycinamidine cyclo-ligase; PFAM- AIR synthase related protein; AIR synthase related protein domain protein (329 aa)
 
 
  0.979
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (435 aa)
 
  0.978
Cpar_0686
PFAM- tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG- cte-CT0719 methylenetetrahydrofolate dehydrogenase (296 aa)
   
  0.977
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine (497 aa)
 
 
  0.968
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (494 aa)
   
 
  0.965
purT
Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family (392 aa)
   
  0.956
Your Current Organism:
Chlorobaculum parvum
NCBI taxonomy Id: 517417
Other names: C. parvum NCIB 8327, Chlorobaculum parvum, Chlorobaculum parvum NCIB 8327, Chlorobaculum parvum str. NCIB 8327, Chlorobaculum parvum strain NCIB 8327
Server load: low (11%) [HD]