STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (147 aa)    
Predicted Functional Partners:
Ctha_2313
PFAM: thymidine kinase; KEGG: sru:SRU_2559 thymidine kinase.
   
 
 0.975
Ctha_2080
PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cph:Cpha266_0943 CMP/dCMP deaminase, zinc-binding.
  
 0.941
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.940
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 
 0.928
Ctha_1238
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.927
Ctha_0685
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; KEGG: sat:SYN_03522 anaerobic ribonucleoside triphosphate reductase.
    
 0.924
Ctha_1941
Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
  
 0.912
Ctha_1064
KEGG: cch:Cag_0703 ribonucleotide-diphosphate reductase subunit alpha; TIGRFAM: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; PFAM: ribonucleotide reductase large subunit; Ribonucleotide reductase class II vitamin B12-dependent; SMART: Hedgehog/intein hint domain protein.
 
  
 0.906
Ctha_0342
PFAM: 5'-Nucleotidase domain protein; KEGG: syn:sll0654 alkaline phosphatase.
     
  0.900
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.900
Your Current Organism:
Chloroherpeton thalassium
NCBI taxonomy Id: 517418
Other names: C. thalassium ATCC 35110, Chloroherpeton thalassium ATCC 35110, Chloroherpeton thalassium str. ATCC 35110, Chloroherpeton thalassium strain ATCC 35110
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