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purH protein (Chloroherpeton thalassium) - STRING interaction network
"purH" - Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase in Chloroherpeton thalassium
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purHBifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (525 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (209 aa)
  0.999
purD
Phosphoribosylamine--glycine ligase (428 aa)
 
  0.997
purM
Phosphoribosylaminoimidazole synthetase (329 aa)
 
 
  0.997
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (235 aa)
 
 
  0.995
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (760 aa)
 
   
  0.991
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (440 aa)
   
  0.990
Ctha_1546
Adenylosuccinate lyase (434 aa)
   
  0.988
Ctha_1197
Inosine-5’-monophosphate dehydrogenase (495 aa)
   
  0.988
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (433 aa)
 
  0.982
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine (492 aa)
 
 
  0.981
Your Current Organism:
Chloroherpeton thalassium
NCBI taxonomy Id: 517418
Other names: C. thalassium, C. thalassium ATCC 35110, Chloroherpeton, Chloroherpeton thalassium, Chloroherpeton thalassium ATCC 35110, Chloroherpeton thalassium str. ATCC 35110, Chloroherpeton thalassium strain ATCC 35110
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