node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ctha_0041 | Ctha_1274 | Ctha_0041 | Ctha_1274 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | 0.566 |
Ctha_0041 | hisA | Ctha_0041 | Ctha_1401 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.805 |
Ctha_0041 | hisB | Ctha_0041 | Ctha_1863 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cph:Cpha266_0929 imidazoleglycerol-phosphate dehydratase. | 0.824 |
Ctha_0041 | hisC | Ctha_0041 | Ctha_0158 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: cte:CT1256 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.566 |
Ctha_0041 | hisD | Ctha_0041 | Ctha_0232 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.718 |
Ctha_0041 | hisF | Ctha_0041 | Ctha_0100 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.866 |
Ctha_0041 | hisG | Ctha_0041 | Ctha_0580 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.524 |
Ctha_0041 | hisH | Ctha_0041 | Ctha_1400 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.808 |
Ctha_0041 | hisI | Ctha_0041 | Ctha_1880 | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.825 |
Ctha_1274 | Ctha_0041 | Ctha_1274 | Ctha_0041 | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | 0.566 |
Ctha_1274 | hisA | Ctha_1274 | Ctha_1401 | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.859 |
Ctha_1274 | hisB | Ctha_1274 | Ctha_1863 | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cph:Cpha266_0929 imidazoleglycerol-phosphate dehydratase. | 0.916 |
Ctha_1274 | hisD | Ctha_1274 | Ctha_0232 | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.901 |
Ctha_1274 | hisF | Ctha_1274 | Ctha_0100 | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.884 |
Ctha_1274 | hisG | Ctha_1274 | Ctha_0580 | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.868 |
Ctha_1274 | hisH | Ctha_1274 | Ctha_1400 | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.899 |
Ctha_1274 | hisI | Ctha_1274 | Ctha_1880 | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.897 |
hisA | Ctha_0041 | Ctha_1401 | Ctha_0041 | KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | KEGG: cph:Cpha266_0250 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | 0.805 |
hisA | Ctha_1274 | Ctha_1401 | Ctha_1274 | KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: aminotransferase class I and II; KEGG: pdi:BDI_2337 L-threonine-O-3-phosphate decarboxylase, putative. | 0.859 |
hisA | hisB | Ctha_1401 | Ctha_1863 | KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cph:Cpha266_0929 imidazoleglycerol-phosphate dehydratase. | 0.977 |