node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ctha_0129 | Ctha_0140 | Ctha_0129 | Ctha_0140 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | 0.923 |
Ctha_0129 | Ctha_0350 | Ctha_0129 | Ctha_0350 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: sru:SRU_0505 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.803 |
Ctha_0129 | Ctha_2180 | Ctha_0129 | Ctha_2180 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: chu:CHU_1086 dihydrolipoyl dehydrogenase (dihydrolipoamide dehydrogenase). | 0.977 |
Ctha_0129 | gcvH | Ctha_0129 | Ctha_1984 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.918 |
Ctha_0129 | gcvPA | Ctha_0129 | Ctha_1983 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.990 |
Ctha_0129 | gcvPB | Ctha_0129 | Ctha_1563 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.997 |
Ctha_0129 | gcvT | Ctha_0129 | Ctha_0507 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
Ctha_0129 | glyA | Ctha_0129 | Ctha_1957 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
Ctha_0129 | purQ | Ctha_0129 | Ctha_0210 | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.810 |
Ctha_0140 | Ctha_0129 | Ctha_0140 | Ctha_0129 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | 0.923 |
Ctha_0140 | Ctha_0350 | Ctha_0140 | Ctha_0350 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: sru:SRU_0505 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.803 |
Ctha_0140 | Ctha_2180 | Ctha_0140 | Ctha_2180 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: chu:CHU_1086 dihydrolipoyl dehydrogenase (dihydrolipoamide dehydrogenase). | 0.977 |
Ctha_0140 | gcvH | Ctha_0140 | Ctha_1984 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.913 |
Ctha_0140 | gcvPA | Ctha_0140 | Ctha_1983 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.991 |
Ctha_0140 | gcvPB | Ctha_0140 | Ctha_1563 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.997 |
Ctha_0140 | gcvT | Ctha_0140 | Ctha_0507 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
Ctha_0140 | glyA | Ctha_0140 | Ctha_1957 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
Ctha_0140 | purQ | Ctha_0140 | Ctha_0210 | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.810 |
Ctha_0350 | Ctha_0129 | Ctha_0350 | Ctha_0129 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: sru:SRU_0505 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | PFAM: glycine cleavage H-protein; KEGG: aby:ABAYE2103 glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor. | 0.803 |
Ctha_0350 | Ctha_0140 | Ctha_0350 | Ctha_0140 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: sru:SRU_0505 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | PFAM: glycine cleavage H-protein; KEGG: aae:aq_944 glycine cleavage system protein H. | 0.803 |