node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | gmK | CMC5_043200 | CMC5_049980 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.972 |
apt | guaA | CMC5_043200 | CMC5_045150 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.991 |
apt | guaB | CMC5_043200 | CMC5_012200 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.585 |
apt | purA-2 | CMC5_043200 | CMC5_060070 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.693 |
apt | purB | CMC5_043200 | CMC5_006150 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.965 |
apt | surE-2 | CMC5_043200 | CMC5_043210 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.967 |
cmk | gmK | CMC5_069010 | CMC5_049980 | Cytidylate kinase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.544 |
cmk | guaA | CMC5_069010 | CMC5_045150 | Cytidylate kinase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.438 |
cmk | guaB | CMC5_069010 | CMC5_012200 | Cytidylate kinase. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.447 |
cmk | purA-2 | CMC5_069010 | CMC5_060070 | Cytidylate kinase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.477 |
cmk | surE-2 | CMC5_069010 | CMC5_043210 | Cytidylate kinase. | 5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.921 |
deoA | guaA | CMC5_039050 | CMC5_045150 | Pyrimidine-nucleoside phosphorylase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.436 |
deoA | guaB | CMC5_039050 | CMC5_012200 | Pyrimidine-nucleoside phosphorylase. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.467 |
deoA | surE-2 | CMC5_039050 | CMC5_043210 | Pyrimidine-nucleoside phosphorylase. | 5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.921 |
deoA | tdk | CMC5_039050 | CMC5_007410 | Pyrimidine-nucleoside phosphorylase. | Thymidine kinase. | 0.931 |
gmK | apt | CMC5_049980 | CMC5_043200 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.972 |
gmK | cmk | CMC5_049980 | CMC5_069010 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Cytidylate kinase. | 0.544 |
gmK | guaA | CMC5_049980 | CMC5_045150 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.971 |
gmK | guaB | CMC5_049980 | CMC5_012200 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.458 |
gmK | purA-2 | CMC5_049980 | CMC5_060070 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.636 |