STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa)    
Predicted Functional Partners:
nfo
Putative endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
  
 
 0.976
rnfE
Electron transport complex subunit RnfE; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
  
 0.965
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.806
patA_1
Putative N-acetyl-LL-diaminopimelate aminotransferase.
 
    0.749
nadE_1
NH(3)-dependent NAD(+) synthetase.
 
    0.735
KXG78723.1
Hypothetical protein.
       0.723
rnfG
Electron transport complex subunit RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
  
  
 0.682
polX_2
DNA polymerase/3'-5' exonuclease PolX.
     
 0.660
fliN
Flagellar motor switch protein FliN.
   
   0.579
epsJ
Putative glycosyltransferase EpsJ.
  
    0.567
Your Current Organism:
Fervidicola ferrireducens
NCBI taxonomy Id: 520764
Other names: DSM 21121, F. ferrireducens, Fervidicola ferrireducens Ogg and Patel 2009, JCM 15106, KCTC 5610, Thermoanaerobacteriaceae bacterium Y170, strain Y170
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