node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mpal_2062 | hisA | Mpal_2062 | Mpal_1746 | PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1718 histidine biosynthesis; Belongs to the HisA/HisF family. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.921 |
Mpal_2062 | hisF | Mpal_2062 | Mpal_0568 | PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1718 histidine biosynthesis; Belongs to the HisA/HisF family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.927 |
Mpal_2062 | hisH | Mpal_2062 | Mpal_2088 | PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1718 histidine biosynthesis; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.900 |
Mpal_2062 | hisI | Mpal_2062 | Mpal_0688 | PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1718 histidine biosynthesis; Belongs to the HisA/HisF family. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.900 |
hisA | Mpal_2062 | Mpal_1746 | Mpal_2062 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1718 histidine biosynthesis; Belongs to the HisA/HisF family. | 0.921 |
hisA | hisB | Mpal_1746 | Mpal_1747 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mbn:Mboo_1067 imidazoleglycerol-phosphate dehydratase. | 0.999 |
hisA | hisC | Mpal_1746 | Mpal_0067 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mem:Memar_1902 histidinol-phosphate aminotransferase. | 0.924 |
hisA | hisD | Mpal_1746 | Mpal_2206 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisE | Mpal_1746 | Mpal_0438 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mem:Memar_1779 phosphoribosyl-ATP pyrophosphohydrolase. | 0.997 |
hisA | hisF | Mpal_1746 | Mpal_0568 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Mpal_1746 | Mpal_1745 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
hisA | hisH | Mpal_1746 | Mpal_2088 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Mpal_1746 | Mpal_0688 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | mat | Mpal_1746 | Mpal_1744 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. | 0.896 |
hisB | hisA | Mpal_1747 | Mpal_1746 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mbn:Mboo_1067 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.999 |
hisB | hisC | Mpal_1747 | Mpal_0067 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mbn:Mboo_1067 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mem:Memar_1902 histidinol-phosphate aminotransferase. | 0.999 |
hisB | hisD | Mpal_1747 | Mpal_2206 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mbn:Mboo_1067 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | Mpal_1747 | Mpal_0438 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mbn:Mboo_1067 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mem:Memar_1779 phosphoribosyl-ATP pyrophosphohydrolase. | 0.997 |
hisB | hisF | Mpal_1747 | Mpal_0568 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mbn:Mboo_1067 imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | Mpal_1747 | Mpal_1745 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mbn:Mboo_1067 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |