STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoApurinic endonuclease Apn1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (286 aa)    
Predicted Functional Partners:
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.890
Mpal_0552
PFAM: 8-oxoguanine DNA glycosylase domain protein; SMART: HhH-GPD family protein; KEGG: mem:Memar_0653 8-oxoguanine DNA glycosylase domain-containing protein.
   
 
 0.652
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
    0.628
Mpal_1740
PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mbn:Mboo_1108 DNA polymerase B region.
 
 
 
 0.613
Mpal_1185
PFAM: DNA polymerase B region; KEGG: mbn:Mboo_1253 DNA polymerase I.
 
 
 
 0.606
Mpal_1699
PFAM: DEAD_2 domain protein; SMART: Helicase-like, DEXD box c2 type; helicase c2; KEGG: mem:Memar_0789 helicase C2.
 
  
 0.598
Mpal_1824
Inorganic diphosphatase; PFAM: CBS domain containing protein; DRTGG domain protein; KEGG: mem:Memar_0491 putative manganese-dependent inorganic pyrophosphatase.
  
    0.576
tyrS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
 
    0.508
Mpal_2532
PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: mem:Memar_1684 phosphoesterase, DHHA1.
 
  
 0.506
Mpal_2660
PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: mem:Memar_0429 phosphoesterase domain-containing protein.
 
  
 0.506
Your Current Organism:
Methanosphaerula palustris
NCBI taxonomy Id: 521011
Other names: Candidatus Methanosphaerula palustris E1-9c, M. palustris E1-9c, Methanosphaerula palustris E1-9c, Methanosphaerula palustris str. E1-9c, Methanosphaerula palustris strain E1-9c
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