STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mpal_2734Pyridoxal-5'-phosphate-dependent protein beta subunit; Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. (425 aa)    
Predicted Functional Partners:
Mpal_2733
KEGG: mem:Memar_0112 thiamine pyrophosphate binding domain-containing protein.
 
   
 0.968
Mpal_2736
PFAM: Fe-S cluster domain protein; KEGG: mbn:Mboo_2115 Fe-S cluster domain-containing protein.
 
     0.927
Mpal_2737
PFAM: cobalamin synthesis protein P47K; KEGG: mem:Memar_0108 cobalamin synthesis protein, P47K.
 
     0.884
Mpal_1993
PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mem:Memar_0971 homoserine dehydrogenase.
 
 
 0.881
Mpal_2735
TIGRFAM: methanogenesis marker 16 metalloprotein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; protein of unknown function DUF39; KEGG: mem:Memar_0110 hypothetical protein.
     
 0.874
Mpal_2738
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mhu:Mhun_2981 ABC transporter related.
 
     0.834
Mpal_0401
KEGG: mbn:Mboo_0087 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family.
  
 
 0.794
Mpal_2113
PFAM: extracellular solute-binding protein family 3; sodium:dicarboxylate symporter; KEGG: mac:MA0491 solute-binding family 3 protein.
     
 0.720
Mpal_0439
TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: mbn:Mboo_2164 D-3-phosphoglycerate dehydrogenase.
 
  
 0.713
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.705
Your Current Organism:
Methanosphaerula palustris
NCBI taxonomy Id: 521011
Other names: Candidatus Methanosphaerula palustris E1-9c, M. palustris E1-9c, Methanosphaerula palustris E1-9c, Methanosphaerula palustris str. E1-9c, Methanosphaerula palustris strain E1-9c
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