node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Kole_0291 | Kole_1686 | Kole_0291 | Kole_1686 | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mch:Mchl_2134 formiminotransferase-cyclodeaminase. | 0.908 |
Kole_0291 | Kole_1720 | Kole_0291 | Kole_1720 | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | 0.900 |
Kole_0291 | Kole_2036 | Kole_0291 | Kole_2036 | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | FolA; KEGG: dat:HRM2_08780 FolA. | 0.920 |
Kole_0291 | fhs | Kole_0291 | Kole_2114 | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: gbe:GbCGDNIH1_0047 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.979 |
Kole_0291 | folD | Kole_0291 | Kole_2113 | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.973 |
Kole_0291 | gcvT | Kole_0291 | Kole_1622 | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.943 |
Kole_0291 | glyA | Kole_0291 | Kole_1456 | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
Kole_0291 | thyX | Kole_0291 | Kole_0028 | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.923 |
Kole_1686 | Kole_0291 | Kole_1686 | Kole_0291 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mch:Mchl_2134 formiminotransferase-cyclodeaminase. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | 0.908 |
Kole_1686 | Kole_1720 | Kole_1686 | Kole_1720 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mch:Mchl_2134 formiminotransferase-cyclodeaminase. | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | 0.997 |
Kole_1686 | fhs | Kole_1686 | Kole_2114 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mch:Mchl_2134 formiminotransferase-cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: gbe:GbCGDNIH1_0047 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.943 |
Kole_1686 | folD | Kole_1686 | Kole_2113 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mch:Mchl_2134 formiminotransferase-cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.935 |
Kole_1686 | gcvT | Kole_1686 | Kole_1622 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mch:Mchl_2134 formiminotransferase-cyclodeaminase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
Kole_1720 | Kole_0291 | Kole_1720 | Kole_0291 | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)-like protein; KEGG: scl:sce3150 IMP cyclohydrolase. | 0.900 |
Kole_1720 | Kole_1686 | Kole_1720 | Kole_1686 | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mch:Mchl_2134 formiminotransferase-cyclodeaminase. | 0.997 |
Kole_1720 | Kole_2036 | Kole_1720 | Kole_2036 | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | FolA; KEGG: dat:HRM2_08780 FolA. | 0.900 |
Kole_1720 | fhs | Kole_1720 | Kole_2114 | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: gbe:GbCGDNIH1_0047 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.907 |
Kole_1720 | folD | Kole_1720 | Kole_2113 | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.907 |
Kole_1720 | gcvT | Kole_1720 | Kole_1622 | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.903 |
Kole_1720 | glyA | Kole_1720 | Kole_1456 | KEGG: aba:Acid345_2130 formiminotransferase-like; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |