STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (610 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 0.990
uvrA
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.905
Aaci_1865
Hypothetical protein.
       0.757
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 
 0.725
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
 
  
 0.689
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.600
Aaci_0682
TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; KEGG: geo:Geob_0379 UvrD/REP helicase.
 
  
 0.586
Aaci_0959
PFAM: UvrD/REP helicase; KEGG: gme:Gmet_0089 ATP-dependent DNA helicase PcrA.
 
  
 0.572
Aaci_1863
TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; PFAM: Fumarate reductase respiratory complex; KEGG: scl:sce8307 succinate dehydrogenase.
       0.535
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.526
Your Current Organism:
Alicyclobacillus acidocaldarius DSM 446
NCBI taxonomy Id: 521098
Other names: A. acidocaldarius subsp. acidocaldarius DSM 446, Alicyclobacillus acidocaldarius subsp. acidocaldarius ATCC 27009, Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446, Alicyclobacillus acidocaldarius subsp. acidocaldarius IFO 15652, Alicyclobacillus acidocaldarius subsp. acidocaldarius JCM 5260, Alicyclobacillus acidocaldarius subsp. acidocaldarius NBRC 15652, Alicyclobacillus acidocaldarius subsp. acidocaldarius NCIB 11725, Alicyclobacillus acidocaldarius subsp. acidocaldarius str. DSM 446, Alicyclobacillus acidocaldarius subsp. acidocaldarius strain DSM 446
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