STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0183Auxin Efflux Carrier; COGs: COG0679 permease; InterPro IPR004776; KEGG: mth:MTH1382 hypothetical protein; PFAM: Auxin Efflux Carrier; SPTR: O27435 Uncharacterized transporter MTH_1382; PFAM: Membrane transport protein; TIGRFAM: he Auxin Efflux Carrier (AEC) Family. (303 aa)    
Predicted Functional Partners:
Mfer_0533
Peptidase M48 Ste24p; COGs: COG0501 Zn-dependent protease with chaperone function; InterPro IPR001915; KEGG: mth:MTH1817 heat shock protein X related protein; PFAM: peptidase M48 Ste24p; SPTR: O27845 Heat shock protein X related protein; PFAM: Peptidase family M48.
  
  
 0.791
htpX
Heat shock protein; COGs: COG0501 Zn-dependent protease with chaperone function; InterPro IPR001915: IPR018247; KEGG: mth:MTH569 heat shock protein X; PFAM: peptidase M48 Ste24p; SPTR: B9AFF5 Putative uncharacterized protein; PFAM: Peptidase family M48; Belongs to the peptidase M48B family.
  
  
 0.791
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
       0.717
Mfer_0181
Nucleic acid binding OB-fold tRNA/helicase-type; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR016027: IPR004365: IPR012340; KEGG: mth:MTH1385 replication factor A; PFAM: nucleic acid binding OB-fold tRNA/helicase-type; SPTR: O27438 Replication factor A related protein; PFAM: Replication factor-A C terminal domain; OB-fold nucleic acid binding domain.
 
     0.702
Mfer_0184
CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
       0.647
coaD
Cytidyltransferase-related domain protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the eukaryotic CoaD family.
  
  
 0.543
Mfer_0185
Protein of unknown function DUF169; COGs: COG2043 conserved hypothetical protein; InterPro IPR003748; KEGG: mth:MTH469 hypothetical protein; PFAM: protein of unknown function DUF169; SPTR: O26569 Conserved protein; PFAM: Uncharacterised ArCR, COG2043.
       0.521
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.445
Mfer_0052
Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR000399: IPR012001: IPR012000: IPR011766: IPR 012846; KEGG: mth:MTH1444 acetolactate synthase catalytic subunit; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: O27493 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP bi [...]
  
  
 0.428
Mfer_0624
Acetolactate synthase; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR000399: IPR000215: IPR012001: IPR012000: IPR 011766; KEGG: mth:MTH1602 acetolactate synthase large subunit-like protein; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; PRIAM: Acetolactate synthase; SPTR: O27639 Acetolactate synthase, large subunit homolog; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiam [...]
  
  
 0.428
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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