STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0241COGs: COG1423 ATP-dependent DNA ligase homolog of eukaryotic ligase III; InterPro IPR012310: IPR001072; KEGG: mth:MTH1221 hypothetical protein; PFAM: ATP dependent DNA ligase; SPTR: O27289 Conserved protein; PFAM: ATP dependent DNA ligase domain; TIGRFAM: RNA ligase, Pab1020 family. (399 aa)    
Predicted Functional Partners:
Mfer_1188
Protein of unknown function UPF0278; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family.
 
     0.799
Mfer_0242
COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR018528: IPR002912; KEGG: mth:MTH1220 chorismate mutase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydratase; SPTR: O27288 Chorismate mutase; PFAM: Prephenate dehydratase; ACT domain.
       0.784
Mfer_0237
COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644: IPR013785; KEGG: mth:MTH1225 inosine-5'-monophosphate dehydrogenase related protein IV; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O27293 Inosine-5'-monophosphate dehydrogenase related protein IV; PFAM: CBS domain.
 
     0.733
Mfer_0240
COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644: IPR013785; KEGG: mth:MTH1222 inosine-5'-monophosphate dehydrogenase related protein I; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O27290 Inosine-5'-monophosphate dehydrogenase related protein I; PFAM: CBS domain.
       0.683
Mfer_0238
COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644: IPR013785; KEGG: mth:MTH1224 inosine-5'-monophosphate dehydrogenase related protein III; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O27292 Inosine-5'-monophosphate dehydrogenase related protein III; PFAM: CBS domain.
       0.676
Mfer_0239
Putative signal transduction protein with CBS domains; COGs: COG2524 transcriptional regulator protein; InterPro IPR000644: IPR013785; KEGG: mth:MTH1223 inosine-5'-monophosphate dehydrogenase related protein II; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O27291 Inosine-5'-monophosphate dehydrogenase related protein II; PFAM: CBS domain.
       0.648
Mfer_0236
Putative signal transduction protein with CBS domains; COGs: COG2524 transcriptional regulator protein; InterPro IPR000644: IPR013785; KEGG: mth:MTH1226 inosine-5'-monophosphate dehydrogenase related protein V; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O27294 Inosine-5'-monophosphate dehydrogenase related protein V; PFAM: CBS domain.
       0.628
Mfer_0243
Protein of unknown function DUF364; COGs: COG2014 conserved hypothetical protein; InterPro IPR007161; KEGG: cma:Cmaq_0299 hypothetical protein; PFAM: protein of unknown function DUF364; SPTR: A8MB57 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF364).
       0.588
Mfer_0244
KEGG: mvu:Metvu_1077 protein of unknown function DUF364; SPTR: C9RH83 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF364).
       0.588
Mfer_0233
Protein of unknown function DUF366; COGs: COG2029 conserved hypothetical protein; InterPro IPR007162; KEGG: mth:MTH1229 hypothetical protein; PFAM: protein of unknown function DUF366; SPTR: O27297 Conserved protein; PFAM: Domain of unknown function (DUF366).
 
     0.544
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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