STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hptPhosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (189 aa)    
Predicted Functional Partners:
guaAB
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 0.990
Mfer_0576
COGs: COG0015 Adenylosuccinate lyase; InterPro IPR002014: IPR020557: IPR000362: IPR003031: IPR 004769: IPR008948: IPR019468; KEGG: mth:MTH1537 adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; SPTR: O27580 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.988
guaAA
GMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP.
  
 
 0.973
Mfer_0189
COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002173: IPR011611: IPR002139; KEGG: mth:MTH1544 ribokinase; PFAM: PfkB domain protein; SPTR: O27587 Uncharacterized sugar kinase MTH_1544; PFAM: pfkB family carbohydrate kinase; Belongs to the carbohydrate kinase PfkB family.
  
 0.966
Mfer_1013
Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
 
    0.964
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.945
ade
COGs: COG1001 Adenine deaminase; InterPro IPR006679: IPR011059: IPR006680; KEGG: chy:CHY_0699 adenine deaminase; PFAM: amidohydrolase; PRIAM: Adenine deaminase; SPTR: Q3AE81 Adenine deaminase 2; TIGRFAM: adenine deaminase; PFAM: Amidohydrolase family; TIGRFAM: adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
    
 0.939
Mfer_0174
Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
  
 
 0.924
purP
IMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
    
  0.903
Mfer_0091
COGs: COG2019 adenylate kinase; KEGG: mth:MTH1663 adenylate kinase; SPTR: O27699 Adenylate kinase homolog MTH_1663; PFAM: ATPase family associated with various cellular activities (AAA).
     
  0.900
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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