| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ71801.1 | EEJ71907.1 | HMPREF0548_1339 | HMPREF0548_1149 | ThiF family protein; COG: COG0476. | Transcriptional regulator, Rrf2 family; COG: COG1959. | 0.632 |
| EEJ71801.1 | iscS | HMPREF0548_1339 | HMPREF0548_0872 | ThiF family protein; COG: COG0476. | Aminotransferase, class V; COG: COG1104. | 0.900 |
| EEJ71801.1 | nifS | HMPREF0548_1339 | HMPREF0548_0180 | ThiF family protein; COG: COG0476. | Aminotransferase, class V; COG: COG1104. | 0.900 |
| EEJ71801.1 | thiI | HMPREF0548_1339 | HMPREF0548_0179 | ThiF family protein; COG: COG0476. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.889 |
| EEJ71907.1 | EEJ71801.1 | HMPREF0548_1149 | HMPREF0548_1339 | Transcriptional regulator, Rrf2 family; COG: COG1959. | ThiF family protein; COG: COG0476. | 0.632 |
| EEJ71907.1 | EEJ72510.1 | HMPREF0548_1149 | HMPREF0548_0634 | Transcriptional regulator, Rrf2 family; COG: COG1959. | SUF system FeS assembly protein, NifU family; COG: COG0822. | 0.684 |
| EEJ71907.1 | iscS | HMPREF0548_1149 | HMPREF0548_0872 | Transcriptional regulator, Rrf2 family; COG: COG1959. | Aminotransferase, class V; COG: COG1104. | 0.834 |
| EEJ71907.1 | nifS | HMPREF0548_1149 | HMPREF0548_0180 | Transcriptional regulator, Rrf2 family; COG: COG1959. | Aminotransferase, class V; COG: COG1104. | 0.834 |
| EEJ72510.1 | EEJ71907.1 | HMPREF0548_0634 | HMPREF0548_1149 | SUF system FeS assembly protein, NifU family; COG: COG0822. | Transcriptional regulator, Rrf2 family; COG: COG1959. | 0.684 |
| EEJ72510.1 | iscS | HMPREF0548_0634 | HMPREF0548_0872 | SUF system FeS assembly protein, NifU family; COG: COG0822. | Aminotransferase, class V; COG: COG1104. | 0.977 |
| EEJ72510.1 | nifS | HMPREF0548_0634 | HMPREF0548_0180 | SUF system FeS assembly protein, NifU family; COG: COG0822. | Aminotransferase, class V; COG: COG1104. | 0.976 |
| acpP | acpP-2 | HMPREF0548_0844 | HMPREF0548_0280 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. | 0.937 |
| acpP | iscS | HMPREF0548_0844 | HMPREF0548_0872 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Aminotransferase, class V; COG: COG1104. | 0.755 |
| acpP | nifS | HMPREF0548_0844 | HMPREF0548_0180 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Aminotransferase, class V; COG: COG1104. | 0.755 |
| acpP-2 | acpP | HMPREF0548_0280 | HMPREF0548_0844 | Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.937 |
| acpP-2 | iscS | HMPREF0548_0280 | HMPREF0548_0872 | Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. | Aminotransferase, class V; COG: COG1104. | 0.755 |
| acpP-2 | nifS | HMPREF0548_0280 | HMPREF0548_0180 | Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. | Aminotransferase, class V; COG: COG1104. | 0.755 |
| clpP | iscS | HMPREF0548_0727 | HMPREF0548_0872 | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Aminotransferase, class V; COG: COG1104. | 0.670 |
| clpP | nifS | HMPREF0548_0727 | HMPREF0548_0180 | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Aminotransferase, class V; COG: COG1104. | 0.670 |
| dltC | iscS | HMPREF0548_1422 | HMPREF0548_0872 | D-alanine--poly(phosphoribitol) ligase, subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | Aminotransferase, class V; COG: COG1104. | 0.755 |