node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS78186.1 | ACS80992.1 | Desal_0115 | Desal_2940 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | 0.609 |
ACS78186.1 | hisA | Desal_0115 | Desal_1557 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | KEGG: dvm:DvMF_3120 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.849 |
ACS78186.1 | hisB | Desal_0115 | Desal_1555 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: dvm:DvMF_3122 imidazoleglycerol-phosphate dehydratase. | 0.879 |
ACS78186.1 | hisC | Desal_0115 | Desal_0178 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: dvl:Dvul_1964 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.609 |
ACS78186.1 | hisD | Desal_0115 | Desal_2020 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.828 |
ACS78186.1 | hisF | Desal_0115 | Desal_1309 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.917 |
ACS78186.1 | hisG | Desal_0115 | Desal_3795 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.624 |
ACS78186.1 | hisH | Desal_0115 | Desal_1310 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.843 |
ACS78186.1 | hisI | Desal_0115 | Desal_3796 | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.880 |
ACS80992.1 | ACS78186.1 | Desal_2940 | Desal_0115 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | KEGG: hha:Hhal_1598 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; HAD-superfamily hydrolase subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase type 3. | 0.609 |
ACS80992.1 | hisA | Desal_2940 | Desal_1557 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | KEGG: dvm:DvMF_3120 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.888 |
ACS80992.1 | hisB | Desal_2940 | Desal_1555 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: dvm:DvMF_3122 imidazoleglycerol-phosphate dehydratase. | 0.993 |
ACS80992.1 | hisC | Desal_2940 | Desal_0178 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: dvl:Dvul_1964 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.913 |
ACS80992.1 | hisD | Desal_2940 | Desal_2020 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.942 |
ACS80992.1 | hisF | Desal_2940 | Desal_1309 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.931 |
ACS80992.1 | hisG | Desal_2940 | Desal_3795 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.887 |
ACS80992.1 | hisH | Desal_2940 | Desal_1310 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.941 |
ACS80992.1 | hisI | Desal_2940 | Desal_3796 | Hpt protein; PFAM: aminotransferase class I and II; KEGG: dvm:DvMF_0908 histidinol-phosphate aminotransferase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.936 |
guaA | hisA | Desal_1552 | Desal_1557 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | KEGG: dvm:DvMF_3120 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.898 |
guaA | hisB | Desal_1552 | Desal_1555 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: dvm:DvMF_3122 imidazoleglycerol-phosphate dehydratase. | 0.590 |