STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)    
Predicted Functional Partners:
ADH63507.1
2-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterPro IPR002020:IPR016141:IPR011278:IPR016142; KEGG: tth:TTC0978 citrate synthase; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: C1XUE1 Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
  
 0.966
ADH63326.1
COGs: COG2225 Malate synthase; InterPro IPR019830:IPR011076:IPR006252; KEGG: rmr:Rmar_2163 malate synthase A; PFAM: Malate synthase family protein; PRIAM: Malate synthase; SPTR: C1XVW8 Malate synthase; TIGRFAM: malate synthase A; PFAM: Malate synthase; TIGRFAM: malate synthase A; Belongs to the malate synthase family.
   
 0.955
ADH63474.1
Transcriptional regulator, IclR family; COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020845:IPR000873:IPR014757:IPR005471; KEGG: tth:TTC0886 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase and ligase; Transcriptional regulator IclR; regulatory protein IclR; SPTR: C1XUH6 Acyl-CoA synthetase/AMP-acid ligase; PFAM: Domain of unknown function (DUF3448); IclR helix-turn-helix domain; Bacterial transcriptional regulator; AMP-binding enzyme.
 
 
0.954
ADH63497.1
COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR016039:IPR002155:IPR016038; KEGG: tth:TTC0191 acetyl-CoA acetyltransferase; SPTR: C1XUF1 Acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.936
ADH64180.1
COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR016039:IPR016038:IPR002155; KEGG: tth:TTC0623 beta-ketoadipyl CoA thiolase; SPTR: C1XPX3 Acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.936
ADH63748.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterProIPR010061:IPR016161:IPR015590:IPR016160:IPR 016162; KEGG: sus:Acid_0680 methylmalonate-semialdehyde dehydrogenase [acylating]; PFAM: Aldehyde Dehydrogenase; SPTR: C1XSY1 Methylmalonate-semialdehyde dehydrogenase (Acylating); TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase.
   
 0.933
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
 
 0.925
ADH63900.1
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 0.921
ADH62385.1
Pyruvate carboxyltransferase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR002034:IPR013785; KEGG: hypothetical protein; PFAM: pyruvate carboxyltransferase; SPTR: C1XQW7 Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.916
ADH64011.1
2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterProIPR005675:IPR013709:IPR000891:IPR013785:IPR 002034; KEGG: tth:TTC0847 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; SPTR: C1XQF9 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family prote [...]
  
 
 0.916
Your Current Organism:
Meiothermus silvanus
NCBI taxonomy Id: 526227
Other names: M. silvanus DSM 9946, Meiothermus silvanus ATCC 700542, Meiothermus silvanus DSM 9946, Meiothermus silvanus VI-R2, Meiothermus silvanus str. DSM 9946, Meiothermus silvanus strain DSM 9946
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