STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
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[Homology]
Score
PAC1Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (440 aa)    
Predicted Functional Partners:
dhc2
Dynein heavy chain.
    
 0.968
dhc1
Dynein heavy chain.
    
 0.968
D8PKS9_SCHCM
NUDE_C domain-containing protein.
    
 
 0.952
D8PNT6_SCHCM
CS domain-containing protein.
    
 0.909
D8Q3G0_SCHCM
WD_REPEATS_REGION domain-containing protein.
   
 0.902
D8PLL3_SCHCM
Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.
     
  0.900
D8QD12_SCHCM
Uncharacterized protein.
    
 0.882
D8Q0Q2_SCHCM
Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
    
 0.845
D8PLZ8_SCHCM
CAP-Gly domain-containing protein.
    
 0.835
D8QBB4_SCHCM
Uncharacterized protein.
    
 0.821
Your Current Organism:
Schizophyllum commune
NCBI taxonomy Id: 578458
Other names: S. commune H4-8, Schizophyllum commune H4-8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.