STRINGSTRING
NTH1 protein (Coprinopsis cinerea) - STRING interaction network
"NTH1" - Endonuclease III homolog in Coprinopsis cinerea
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family (450 aa)    
Predicted Functional Partners:
CC1G_01133
DNA-(apurinic or apyrimidinic site) lyase (304 aa)
 
 
 
  0.907
CC1G_05939
DNA-(apurinic or apyrimidinic site) lyase 2 (609 aa)
 
 
 
  0.903
UNG1
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (329 aa)
   
 
  0.875
CC1G_01194
N-glycosylase/DNA lyase (409 aa)
     
 
  0.873
CC1G_13815
Endonuclease IV (320 aa)
   
 
  0.866
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (422 aa)
   
 
  0.855
CC1G_13604
Hydrophilic protein (312 aa)
     
 
  0.824
CC1G_15688
A/G-specific adenine DNA glycosylase (599 aa)
   
   
  0.812
CC1G_02791
Uncharacterized protein (986 aa)
     
 
  0.790
CC1G_07090
Trehalase; Alpha,alpha-trehalase (774 aa)
           
  0.784
Your Current Organism:
Coprinopsis cinerea
NCBI taxonomy Id: 5346
Other names: C. cinerea, Coprinopsis cinerea, Coprinus cinereus, Coprinus macrorhizus
Server load: low (10%) [HD]