STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CC1G_08181Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (196 aa)    
Predicted Functional Partners:
CC1G_03855
Nucleoside diphosphate kinase.
  
 0.977
CC1G_00237
Adenine phosphoribosyltransferase.
  
 0.977
CC1G_10072
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family.
   
 0.965
CC1G_09717
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
  
 0.964
CC1G_11893
GMP synthase.
  
 
 0.962
CC1G_13164
Guanylate kinase.
  
 
 0.950
CC1G_00125
dUTP pyrophosphatase.
  
 0.937
CC1G_08365
Bifunctional purine biosynthesis protein ade10.
     
 0.932
CC1G_03349
AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
    
 0.927
CC1G_14672
GTP cyclohydrolase I.
  
 
 0.923
Your Current Organism:
Coprinopsis cinerea
NCBI taxonomy Id: 240176
Other names: C. cinerea okayama7#130, Coprinopsis cinerea okayama7#130, Coprinus cinereus okayama7#130
Server load: low (30%) [HD]