node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Htur_3206 | dbh | Htur_3206 | Htur_2100 | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.470 |
Htur_3206 | dnaK | Htur_3206 | Htur_2013 | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | Chaperone protein DnaK; Acts as a chaperone. | 0.419 |
Htur_3206 | gyrB | Htur_3206 | Htur_2271 | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.538 |
Htur_3206 | ligA | Htur_3206 | Htur_3645 | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.753 |
Htur_3206 | mutL | Htur_3206 | Htur_3218 | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.620 |
Htur_3206 | uvrA | Htur_3206 | Htur_3091 | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.611 |
Htur_3206 | uvrB | Htur_3206 | Htur_3701 | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.715 |
Htur_3206 | uvrC | Htur_3206 | Htur_3639 | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.750 |
Htur_3265 | dbh | Htur_3265 | Htur_2100 | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.483 |
Htur_3265 | dnaK | Htur_3265 | Htur_2013 | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | Chaperone protein DnaK; Acts as a chaperone. | 0.449 |
Htur_3265 | gyrB | Htur_3265 | Htur_2271 | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.502 |
Htur_3265 | ligA | Htur_3265 | Htur_3645 | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.777 |
Htur_3265 | mutL | Htur_3265 | Htur_3218 | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.620 |
Htur_3265 | uvrA | Htur_3265 | Htur_3091 | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.672 |
Htur_3265 | uvrB | Htur_3265 | Htur_3701 | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.758 |
Htur_3265 | uvrC | Htur_3265 | Htur_3639 | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.932 |
dbh | Htur_3206 | Htur_2100 | Htur_3206 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | PFAM: UvrD/REP helicase; KEGG: scl:sce7600 ATP-dependent DNA helicase. | 0.470 |
dbh | Htur_3265 | Htur_2100 | Htur_3265 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | PFAM: UvrD/REP helicase; KEGG: hch:HCH_00743 DNA-dependent helicase II. | 0.483 |
dbh | dnaK | Htur_2100 | Htur_2013 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | Chaperone protein DnaK; Acts as a chaperone. | 0.486 |
dbh | gyrB | Htur_2100 | Htur_2271 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.539 |