node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACO46605.1 | folD | Deide_16360 | Deide_16010 | Putative Phosphoribosylglycinamide formyltransferase. | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.957 |
ACO46605.1 | glyA | Deide_16360 | Deide_20930 | Putative Phosphoribosylglycinamide formyltransferase. | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
ACO46605.1 | purA | Deide_16360 | Deide_02690 | Putative Phosphoribosylglycinamide formyltransferase. | Adenylosuccinate synthetase (IMP--aspartate ligase) (AdSS) (AMPSase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.566 |
ACO46605.1 | purB | Deide_16360 | Deide_16710 | Putative Phosphoribosylglycinamide formyltransferase. | Putative adenylosuccinate lyase (Adenylosuccinase); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.882 |
ACO46605.1 | purC | Deide_16360 | Deide_21270 | Putative Phosphoribosylglycinamide formyltransferase. | Putative Phosphoribosylaminoimidazolesuccinocarboxamide synthase (SAICAR synthetase) (Phosphoribosylaminoimidazole-succinocarboxamide synthetase). | 0.972 |
ACO46605.1 | purD | Deide_16360 | Deide_11050 | Putative Phosphoribosylglycinamide formyltransferase. | Putative phosphoribosylamine--glycine ligase (Glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); Belongs to the GARS family. | 0.999 |
ACO46605.1 | purE | Deide_16360 | Deide_02880 | Putative Phosphoribosylglycinamide formyltransferase. | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.974 |
ACO46605.1 | purF | Deide_16360 | Deide_21330 | Putative Phosphoribosylglycinamide formyltransferase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.980 |
ACO46605.1 | purH | Deide_16360 | Deide_16000 | Putative Phosphoribosylglycinamide formyltransferase. | Bifunctional purine biosynthesis protein PurH; [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); IMP cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]. | 0.999 |
ACO46605.1 | purM | Deide_16360 | Deide_14110 | Putative Phosphoribosylglycinamide formyltransferase. | Putative Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase). | 0.997 |
folD | ACO46605.1 | Deide_16010 | Deide_16360 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative Phosphoribosylglycinamide formyltransferase. | 0.957 |
folD | glyA | Deide_16010 | Deide_20930 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
folD | purA | Deide_16010 | Deide_02690 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate synthetase (IMP--aspartate ligase) (AdSS) (AMPSase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.562 |
folD | purB | Deide_16010 | Deide_16710 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative adenylosuccinate lyase (Adenylosuccinase); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.653 |
folD | purD | Deide_16010 | Deide_11050 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative phosphoribosylamine--glycine ligase (Glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); Belongs to the GARS family. | 0.456 |
folD | purE | Deide_16010 | Deide_02880 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.410 |
folD | purF | Deide_16010 | Deide_21330 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.452 |
folD | purH | Deide_16010 | Deide_16000 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Bifunctional purine biosynthesis protein PurH; [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); IMP cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]. | 0.992 |
folD | purM | Deide_16010 | Deide_14110 | Putative bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase). | 0.491 |
glyA | ACO46605.1 | Deide_20930 | Deide_16360 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative Phosphoribosylglycinamide formyltransferase. | 0.964 |