STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
EEF76234.1Threonine-phosphate decarboxylase; KEGG: bfr:BF2490 1.1e-111 cobC; aminotransferase involved in cobalamin biosynthesis CobC K00817. (337 aa)    
Predicted Functional Partners:
cobD
Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
 0.994
hisB
Histidinol-phosphatase; KEGG: bth:BT0203 1.4e-166 hisB; histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase K01089:K01693; Psort location: Cytoplasmic, score: 8.96; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
 0.993
cobQ
Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
 0.993
cobB
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
 0.993
hisE
KEGG: bfr:BF3052 2.7e-90 phosphoribosyl-ATP pyrophosphohydrolase K01496:K01523; Psort location: Cytoplasmic, score: 9.97; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.980
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.941
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.920
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.906
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.871
hisA
KEGG: bfs:BF2890 2.0e-85 hisA; imidazole-4-carboxamide isomerase K01814; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.847
Your Current Organism:
Bacteroides coprophilus
NCBI taxonomy Id: 547042
Other names: B. coprophilus DSM 18228 = JCM 13818, Bacteroides coprophilus CB42, Bacteroides coprophilus DSM 18228, Bacteroides coprophilus DSM 18228 = JCM 13818, Bacteroides coprophilus JCM 13818, Bacteroides coprophilus JCM 13818 = DSM 18228
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