STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGG15673.1Citrate synthase; IMG reference gene:2506378286; PFAM: Citrate synthase; PFAM: Citrate synthase; SPTR: Citrate synthase; KEGG: tal:Thal_1455 citrate synthase; COGs: COG0372 Citrate synthase; InterPro IPR002020. (257 aa)    
Predicted Functional Partners:
AGG15571.1
Succinate--CoA ligase (ADP-forming); IMG reference gene:2506378174; PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; PRIAM: Succinate--CoA ligase (ADP-forming); PFAM: ATP-grasp domain protein; SPTR: Succinate--CoA ligase (ADP-forming); KEGG: tal:Thal_0201 succinate--CoA ligase (ADP-forming); COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650.
 
 0.996
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.995
AGG14429.1
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 0.989
AGG15671.1
acetyl-CoA carboxylase, biotin carboxylase; IMG reference gene:2506378284; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase subunit; TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; SPTR: Acetyl-CoA carboxylase, biotin carboxylase; KEGG: hth:HTH_1917 biotin carboxylase; COGs: [...]
  
 
 0.980
AGG15570.1
CoA-binding domain protein; IMG reference gene:2506378173; PFAM: CoA binding domain; CoA-ligase; TIGRFAM: succinyl-CoA synthetase, alpha subunit; PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase; SPTR: CoA-binding domain protein; KEGG: tal:Thal_0200 succinate--CoA ligase (ADP-forming); COGs: COG0074 Succinyl-CoA synthetase alpha subunit; InterPro IPR005810:IPR003781:IPR005811.
 0.979
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.957
AGG14928.1
Aconitase; IMG reference gene:2506377493; PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase, putative, Aquifex type; KEGG: hth:HTH_0755 aconitate hydratase/aconitase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain-containing protein; SPTR: Aconitate hydratase; COGs: COG1048 Aconitase A; InterPro IPR006250:IPR001030:IPR018136:IPR000573.
 
 0.954
AGG15722.1
Isocitrate dehydrogenase (NADP(+)); IMG reference gene:2506378338; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type; PRIAM: Isocitrate dehydrogenase (NADP(+)); PFAM: isocitrate/isopropylmalate dehydrogenase; SPTR: Isocitrate dehydrogenase (NADP(+)); KEGG: saf:SULAZ_0526 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific IcdH) (idp); COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804.
 
 
 0.948
AGG14950.1
Oxaloacetate decarboxylase alpha subunit; IMG reference gene:2506377518; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: oxaloacetate decarboxylase alpha subunit; TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; SPTR: Oxaloacetate decarboxylase alpha subunit; KEGG: aae:aq_1614 pyruvate carboxylase subunit B; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterProIPR005776:IPR001882:IPR000891:IPR003379:IPR 000089.
   
 
 0.943
accD
acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
    
 0.921
Your Current Organism:
Hydrogenobaculum sp. HO
NCBI taxonomy Id: 547144
Other names: H. sp. HO
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