STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (561 aa)    
Predicted Functional Partners:
Mmah_0746
DNA ligase D, 3'-phosphoesterase domain protein; InterPro IPR014144; KEGG: cbc:CbuK_0042 ATP-dependent DNA ligase; SPTR: Q8Q0C8 Putative uncharacterized protein; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain.
   
 0.919
pcn
Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 0.912
lig-2
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
  
 
0.911
Mmah_1090
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR002008:IPR004013:IPR002054:IPR003141:IPR 003583; KEGG: cbc:CbuK_1370 DNA polymerase X family; PFAM: PHP domain protein; SMART: DNA polymerase X; phosphoesterase PHP domain protein; Helix-hairpin-helix DNA-binding class 1; SPTR: Q46C05 DNA polymerase X family / putative histidinol phosphatase; PFAM: PHP domain.
 
 0.868
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
 
 0.849
Mmah_0568
COGs: COG0460 Homoserine dehydrogenase; InterPro IPR001342:IPR005106; KEGG: pfl:PFL_3809 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; PRIAM: Homoserine dehydrogenase; SPTR: Q12X09 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase.
       0.800
Mmah_0569
COGs: COG2061 ACT-domain-containing protein predicted allosteric regulator of homoserine dehydrogenase; SPTR: Q12X10 Putative uncharacterized protein.
       0.787
Mmah_1995
COGs: COG0417 DNA polymerase elongation subunit (family B); InterProIPR017966:IPR006134:IPR006133:IPR006172:IPR 017964:IPR004578; KEGG: CaJ7_0319; hypothetical protein; K02327 DNA polymerase delta subunit 1; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: Q12VE4 DNA polymerase; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; TIGRFAM: DNA polymerase (pol2).
  
 0.697
Mmah_0334
COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR000097:IPR004808; KEGG: dde:Dde_0551 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SPTR: Q12U61 Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
  
 
 0.652
mre11
Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
 
 0.574
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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