STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
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[Homology]
Score
psmBProteasome endopeptidase complex, beta component; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (210 aa)    
Predicted Functional Partners:
psmA
Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.999
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
 
 0.914
Mmah_0449
Proteasome-activating nucleotidase; COGs: COG1222 ATP-dependent 26S proteasome regulatory subunit; InterProIPR003959:IPR011704:IPR003593:IPR003960:IPR 005937; KEGG: hypothetical protein; K03066 26S proteasome regulatory subunit T6; PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; PRIAM: Adenosinetriphosphatase; SMART: AAA ATPase; SPTR: Q12TR9 26S proteasome subunit P45 family; TIGRFAM: 26S proteasome subunit P45 family; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: 26S proteasome subunit P45 family.
  
 0.903
Mmah_0694
Mov34/MPN/PAD-1 family protein; COGs: COG1310 metal-dependent protease of the PAD1/JAB1 superfamily; InterPro IPR000555; KEGG: wsu:WS1005 hypothetical protein; PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; SPTR: Q0W197 Predicted protease (Mov34 family); PFAM: Mov34/MPN/PAD-1 family.
   
 0.858
Mmah_0889
Proteasome Rpn11 subunit JAMM motif protein; COGs: COG1310 metal-dependent protease of the PAD1/JAB1 superfamily; SPTR: Q12Y82 JAMM-like protein. Metallo peptidase. MEROPS family M67B.
   
 0.858
rpl40e
SPTR: Q12VH3 50S ribosomal protein L40e; PFAM: Ribosomal L40e family; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.848
Mmah_0754
KH-domain/beta-lactamase-domain protein; COGs: COG1782 metal-dependent RNase consists of a metallo-beta-lactamase domain and an RNA-binding KH domain; InterProIPR001279:IPR018111:IPR011108:IPR004087:IPR 004088:IPR019756:IPR019975; KEGG: Cpsf3l; cleavage and polyadenylation specific factor 3-like; PFAM: beta-lactamase domain protein; K Homology, type 1, subgroup; RNA-metabolising metallo-beta-lactamase; SMART: KH domain protein; SPTR: Q12YV6 Beta-lactamase-like protein; TIGRFAM: KH-domain/beta-lactamase-domain protein; PFAM: KH domain; Metallo-beta-lactamase superfamily; RNA-metabolisin [...]
 
   
 0.743
Mmah_0190
AAA ATPase central domain protein; COGs: COG0464 ATPase of the AAA+ class; InterPro IPR003959:IPR011704:IPR003593:IPR003960; KEGG: sfu:Sfum_2326 ATPase central domain-containing protein; PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; SPTR: Q12UP0 AAA ATPase; PFAM: ATPase family associated with various cellular activities (AAA).
  
 0.724
Mmah_0251
AAA family ATPase, CDC48 subfamily; COGs: COG0464 ATPase of the AAA+ class; InterProIPR004201:IPR003959:IPR011704:IPR003338:IPR 003593:IPR003960:IPR005938; KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; PRIAM: Adenosinetriphosphatase; SMART: AAA ATPase; SPTR: Q12UG4 AAA family ATPase, CDC48 subfamily; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: Cell division protein 48 (CDC48), N-terminal domai [...]
  
 0.724
Mmah_0619
Adenosinetriphosphatase; COGs: COG0464 ATPase of the AAA+ class; InterPro IPR003959:IPR011704:IPR003593:IPR003960; KEGG: CDC48; microsomal protein of CDC48 family of ATPases; PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; PRIAM: Adenosinetriphosphatase; SMART: AAA ATPase; SPTR: B5IEZ0 AAA family ATPase, CDC48 subfamily; PFAM: ATPase family associated with various cellular activities (AAA).
  
 0.724
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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