STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
lig-2DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (569 aa)    
Predicted Functional Partners:
Mmah_1090
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR002008:IPR004013:IPR002054:IPR003141:IPR 003583; KEGG: cbc:CbuK_1370 DNA polymerase X family; PFAM: PHP domain protein; SMART: DNA polymerase X; phosphoesterase PHP domain protein; Helix-hairpin-helix DNA-binding class 1; SPTR: Q46C05 DNA polymerase X family / putative histidinol phosphatase; PFAM: PHP domain.
 
 0.972
Mmah_0746
DNA ligase D, 3'-phosphoesterase domain protein; InterPro IPR014144; KEGG: cbc:CbuK_0042 ATP-dependent DNA ligase; SPTR: Q8Q0C8 Putative uncharacterized protein; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain.
   
 0.943
pcn
Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 0.912
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
  
 
0.911
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
 
 0.855
Mmah_1995
COGs: COG0417 DNA polymerase elongation subunit (family B); InterProIPR017966:IPR006134:IPR006133:IPR006172:IPR 017964:IPR004578; KEGG: CaJ7_0319; hypothetical protein; K02327 DNA polymerase delta subunit 1; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: Q12VE4 DNA polymerase; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; TIGRFAM: DNA polymerase (pol2).
  
 0.697
Mmah_0334
COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR000097:IPR004808; KEGG: dde:Dde_0551 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SPTR: Q12U61 Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
  
 
 0.652
Mmah_0229
Replication factor C; COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR013748; KEGG: hypothetical protein; K10756 replication factor C subunit 3/5; PFAM: Replication factor C; SPTR: Q12UK9 Replication factor C small subunit; PFAM: ATPase family associated with various cellular activities (AAA); Replication factor C.
  
 0.579
rfcL
Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
  
 0.566
rfcS
Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily.
  
 0.563
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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