STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
hptPhosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (190 aa)    
Predicted Functional Partners:
Mmah_0591
COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362:IPR019468:IPR020557:IPR004769; KEGG: nam:NAMH_1763 adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; SPTR: Q8TJ18 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.986
guaAB
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 0.983
Mmah_0649
COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002139:IPR011611:IPR002173; KEGG: afr:AFE_0530 carbohydrate kinase, PfkB family; PFAM: PfkB domain protein; SPTR: Q12XB8 Cytidine kinase / inosine-guanosine kinase; PFAM: pfkB family carbohydrate kinase; Belongs to the carbohydrate kinase PfkB family.
 
 0.974
Mmah_0142
IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607:IPR013982:IPR002695; KEGG: gsu:GSU0609 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: Q12UR7 Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cycloh [...]
  
 0.973
guaAA
GMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP.
 
 
 0.973
Mmah_0526
COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611:IPR002173; KEGG: noc:Noc_2548 carbohydrate kinase, PfkB; PFAM: PfkB domain protein; PRIAM: Adenosine kinase; SPTR: A2WCU5 Sugar kinase; PFAM: pfkB family carbohydrate kinase.
  
 0.970
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
 
 
 0.966
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.932
Mmah_0871
CMP/dCMP deaminase zinc-binding protein; COGs: COG0590 Cytosine/adenosine deaminase; InterPro IPR002125:IPR016192; KEGG: tdn:Suden_1831 guanine deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Q12ZA1 CMP/dCMP deaminase, zinc-binding; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region.
     
 0.911
Mmah_1509
Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
   
 
 0.909
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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