STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuBKEGG: hla:Hlac_0870 isocitrate/isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (327 aa)    
Predicted Functional Partners:
leuD
KEGG: nph:NP2192A 3-isopropylmalate dehydratase, small subunit; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein.
 
 
 0.998
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.998
ilvN
KEGG: nph:NP2200A acetolactate synthase small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein.
  
 0.994
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.970
ilvB1
KEGG: nph:NP2202A acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region.
 
 0.968
ilvD
TIGRFAM: dihydroxy-acid dehydratase; KEGG: nph:NP4926A dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.955
Nmag_2521
Homolog to acetolactate synthase large subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: hma:rrnAC0134 acetolactate synthase large subunit; Belongs to the TPP enzyme family.
  
 0.952
ilvA1
KEGG: hma:rrnAC2508 threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein.
  
 
 0.940
ilvA
KEGG: hma:pNG7371 threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein.
  
 
 0.940
leuA1
2-isopropylmalate synthase; PFAM: pyruvate carboxyltransferase; KEGG: hla:Hlac_0876 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.908
Your Current Organism:
Natrialba magadii
NCBI taxonomy Id: 547559
Other names: N. magadii ATCC 43099, Natrialba magadii ATCC 43099, Natrialba magadii DSM 3394, Natrialba magadii MS3, Natrialba magadii NCIMB 2190, Natrialba magadii str. ATCC 43099, Natrialba magadii strain ATCC 43099
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