STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cofC2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (236 aa)    
Predicted Functional Partners:
cofD
2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
  
 0.975
cofG
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
 
   
 0.801
cofE
Coenzyme F420:L-glutamate ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
 
   
 0.756
Nmag_2514
PFAM: amino acid-binding ACT domain protein; KEGG: hmu:Hmuk_0499 amino acid-binding ACT domain protein.
  
     0.729
dpd
KEGG: hma:rrnAC0052 dihydropyrimidine dehydrogenase.
 
     0.726
Nmag_0619
DHH/RecJ family phosphoesterase; PFAM: phosphoesterase RecJ domain protein; nucleic acid binding OB-fold tRNA/helicase-type; KEGG: nph:NP3224A uncharacterized protein.
  
     0.726
oapB
Origin-associated protein OapB; PFAM: uncharacterized protein; KEGG: hut:Huta_1616 uncharacterized protein.
  
     0.724
Nmag_3221
PFAM: Protein of unknown function UPF0058; KEGG: hla:Hlac_1490 protein of unknown function UPF0058.
  
     0.718
Nmag_0304
PFAM: Protein of unknown function DUF293; KEGG: hwa:HQ2649A transcriptional regulator.
  
     0.709
Nmag_2506
arNOG05395 family transcription regulator; KEGG: nph:NP1628A uncharacterized protein; PFAM: regulatory protein IclR; SMART: regulatory protein Crp.
  
     0.707
Your Current Organism:
Natrialba magadii
NCBI taxonomy Id: 547559
Other names: N. magadii ATCC 43099, Natrialba magadii ATCC 43099, Natrialba magadii DSM 3394, Natrialba magadii MS3, Natrialba magadii NCIMB 2190, Natrialba magadii str. ATCC 43099, Natrialba magadii strain ATCC 43099
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