STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PKH1Serine/threonine-protein kinase PKH2; Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P- body assembly and regulates global mRNA decay at the deadenylation step (1153 aa)    
Predicted Functional Partners:
PKC1
annotation not available
   
0.954
TOR1
annotation not available
   
 
 0.887
PIL1
annotation not available
    
 
 0.852
NCE102
Non-classical export protein 102; Involved in membrane organization. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. Non-classical export pathway functions also as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient (By similarity). Regulates actin organization and subsequent morphogenesis and pathogenesis
      
 0.816
SCH9
Serine/threonine-protein kinase SCH9; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway (By similarity). Plays a role in filamentous growth and virulence. Prevents hypha formation specifically under hypoxia at high CO(2) levels. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens
   
 
0.787
orf19.3699
annotation not available
   
  
 0.786
PDK2
annotation not available
    
 
 0.768
orf19.399
annotation not available
   
 
0.759
orf19.6275
annotation not available
   
 
0.715
SLM2
annotation not available
    
 
 0.714
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 5476
Other names: ATCC 11006 [[Candida stellatoidea]], ATCC 18804, ATCC 20308, BCC 5390, BCRC 20512, C. albicans, CBS 562, CCRC 20512, Candida albicans, Candida stellatoidea, Candida stellatoidea type I, KCTC 7270, MUCL 29800, NBIMCC 72, NCAIM Y.00971, NCYC 597, NRRL Y-12983, PYCC 3436, UAMH 8765
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