node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUR1 | BUR2 | Q6FQ83 | Q6FX19 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | 0.996 |
BUR1 | Q6FMU5_CANGA | Q6FQ83 | Q6FMU5 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | CYCLIN domain-containing protein; Belongs to the cyclin family. | 0.702 |
BUR1 | Q6FP45_CANGA | Q6FQ83 | Q6FP45 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | CTK3_C domain-containing protein. | 0.806 |
BUR1 | Q6FR98_CANGA | Q6FQ83 | Q6FR98 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.734 |
BUR1 | Q6FW48_CANGA | Q6FQ83 | Q6FW48 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | Uncharacterized protein; Belongs to the cyclin family. | 0.923 |
BUR1 | Q6FW93_CANGA | Q6FQ83 | Q6FW93 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | Protein kinase domain-containing protein. | 0.553 |
BUR1 | RPB1 | Q6FQ83 | Q6FQS9 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.977 |
BUR1 | SPT4 | Q6FQ83 | Q6FMX1 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). | 0.784 |
BUR1 | SPT5 | Q6FQ83 | Q6FRZ5 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). | 0.953 |
BUR2 | BUR1 | Q6FX19 | Q6FQ83 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | 0.996 |
BUR2 | Q6FMU5_CANGA | Q6FX19 | Q6FMU5 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | CYCLIN domain-containing protein; Belongs to the cyclin family. | 0.871 |
BUR2 | Q6FP45_CANGA | Q6FX19 | Q6FP45 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | CTK3_C domain-containing protein. | 0.786 |
BUR2 | Q6FR98_CANGA | Q6FX19 | Q6FR98 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.873 |
BUR2 | Q6FW48_CANGA | Q6FX19 | Q6FW48 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | Uncharacterized protein; Belongs to the cyclin family. | 0.774 |
BUR2 | Q6FW93_CANGA | Q6FX19 | Q6FW93 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | Protein kinase domain-containing protein. | 0.932 |
BUR2 | RPB1 | Q6FX19 | Q6FQS9 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.924 |
BUR2 | SPT4 | Q6FX19 | Q6FMX1 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). | 0.858 |
BUR2 | SPT5 | Q6FX19 | Q6FRZ5 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). | 0.898 |
BUR2 | SSN8 | Q6FX19 | Q6FJE8 | Protein BUR2; Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin- conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone- induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity). | RNA polymerase II holoenzyme cyclin-like subunit; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By s [...] | 0.786 |
Q6FMU5_CANGA | BUR1 | Q6FMU5 | Q6FQ83 | CYCLIN domain-containing protein; Belongs to the cyclin family. | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). | 0.702 |