STRINGSTRING
ilvD protein (Dehalogenimonas lykanthroporepellens) - STRING interaction network
"ilvD" - TIGRFAM: dihydroxy-acid dehydratase in Dehalogenimonas lykanthroporepellens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDTIGRFAM- dihydroxy-acid dehydratase; KEGG- dev-DhcVS_738 dihydroxy-acid dehydratase; PFAM- dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family (555 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (334 aa)
 
  0.999
Dehly_0666
KEGG- det-DET0833 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM- acetolactate synthase, large subunit, biosynthetic type; PFAM- thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding (562 aa)
 
  0.998
Dehly_0667
KEGG- deg-DehalGT_0712 acetolactate synthase, small subunit; TIGRFAM- acetolactate synthase, small subunit; PFAM- Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein (169 aa)
 
 
  0.983
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family (303 aa)
   
  0.977
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily (513 aa)
 
 
  0.965
Dehly_0674
KEGG- deb-DehaBAV1_0744 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM- 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM- pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family (529 aa)
   
 
  0.955
Dehly_1331
KEGG- deg-DehalGT_1408 (R)-citramalate synthase; PFAM- pyruvate carboxyltransferase (429 aa)
 
 
  0.935
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate; Belongs to the PanB family (282 aa)
     
 
  0.927
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (566 aa)
   
   
  0.907
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (362 aa)
 
   
  0.846
Your Current Organism:
Dehalogenimonas lykanthroporepellens
NCBI taxonomy Id: 552811
Other names: Chloroflexi bacterium BL-DC-8, Chloroflexi bacterium BL-DC-9, D. lykanthroporepellens BL-DC-9, Dehalogenimonas lykanthroporepellens, Dehalogenimonas lykanthroporepellens BL-DC-9, Dehalogenimonas lykanthroporepellens str. BL-DC-9, Dehalogenimonas lykanthroporepellens strain BL-DC-9
Server load: low (15%) [HD]