node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACX95742.1 | ACX95992.1 | Hneap_0899 | Hneap_1156 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | 0.910 |
ACX95742.1 | ACX96479.1 | Hneap_0899 | Hneap_1653 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.910 |
ACX95742.1 | ACX96935.1 | Hneap_0899 | Hneap_2118 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sfr:Sfri_3161 short chain dehydrogenase. | 0.901 |
ACX95742.1 | thyA | Hneap_0899 | Hneap_0901 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
ACX95968.1 | ACX95992.1 | Hneap_1132 | Hneap_1156 | KEGG: asu:Asuc_1732 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | 0.843 |
ACX95968.1 | ACX96791.1 | Hneap_1132 | Hneap_1969 | KEGG: asu:Asuc_1732 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
ACX95991.1 | ACX95992.1 | Hneap_1155 | Hneap_1156 | PFAM: Sporulation domain protein; KEGG: tgr:Tgr7_1257 sporulation domain protein. | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | 0.912 |
ACX95991.1 | accD | Hneap_1155 | Hneap_1157 | PFAM: Sporulation domain protein; KEGG: tgr:Tgr7_1257 sporulation domain protein. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.840 |
ACX95991.1 | trpF | Hneap_1155 | Hneap_1160 | PFAM: Sporulation domain protein; KEGG: tgr:Tgr7_1257 sporulation domain protein. | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: hypothetical protein; Belongs to the TrpF family. | 0.742 |
ACX95991.1 | truA | Hneap_1155 | Hneap_1161 | PFAM: Sporulation domain protein; KEGG: tgr:Tgr7_1257 sporulation domain protein. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.616 |
ACX95992.1 | ACX95742.1 | Hneap_1156 | Hneap_0899 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.910 |
ACX95992.1 | ACX95968.1 | Hneap_1156 | Hneap_1132 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | KEGG: asu:Asuc_1732 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. | 0.843 |
ACX95992.1 | ACX95991.1 | Hneap_1156 | Hneap_1155 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | PFAM: Sporulation domain protein; KEGG: tgr:Tgr7_1257 sporulation domain protein. | 0.912 |
ACX95992.1 | ACX96479.1 | Hneap_1156 | Hneap_1653 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.910 |
ACX95992.1 | ACX96791.1 | Hneap_1156 | Hneap_1969 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
ACX95992.1 | ACX96935.1 | Hneap_1156 | Hneap_2118 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sfr:Sfri_3161 short chain dehydrogenase. | 0.900 |
ACX95992.1 | accD | Hneap_1156 | Hneap_1157 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.931 |
ACX95992.1 | thyA | Hneap_1156 | Hneap_0901 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.859 |
ACX95992.1 | trpF | Hneap_1156 | Hneap_1160 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: hypothetical protein; Belongs to the TrpF family. | 0.816 |
ACX95992.1 | truA | Hneap_1156 | Hneap_1161 | KEGG: mei:Msip34_1543 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the folylpolyglutamate synthase family. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.813 |