STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ldh-2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (324 aa)    
Predicted Functional Partners:
Lreu_0751
TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family.
  
 0.948
Lreu_1532
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); PFAM: malic protein domain protein; malic protein, NAD-binding.
  
 0.925
Lreu_0632
Transketolase domain protein; PFAM: Transketolase, central region; Transketolase domain protein.
   
 0.917
pdhA
Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
   
 
 0.909
Lreu_0043
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.
  
 0.882
Lreu_0683
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.
  
 0.882
Lreu_1631
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.
  
 0.882
Lreu_1692
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.
  
 0.882
pgi
PFAM: phosphoglucose isomerase (PGI); Belongs to the GPI family.
  
 
 0.860
Lreu_0238
TIGRFAM: ketose-bisphosphate aldolase; fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase, class-II.
   
 
 0.827
Your Current Organism:
Lactobacillus reuteri
NCBI taxonomy Id: 557436
Other names: L. reuteri DSM 20016, Lactobacillus reuteri DSM 20016, Lactobacillus reuteri str. DSM 20016, Lactobacillus reuteri strain DSM 20016
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.