STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (406 aa)    
Predicted Functional Partners:
cyaY
Frataxin-like protein implicated in iron transport; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
   
 0.999
iscU
Scaffold protein, NifU-like protein involved in Fe-S cluster formation; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.999
fdx
Ferredoxin, 2Fe-2S type, ISC system; COG:C;COG0633.
 
 0.987
sirA-3
Sulfur carrier protein TusA; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family.
   
 0.986
thiI
Thiamine biosynthesis protein ThiI/thiamine biosynthesis ATP pyrophosphatase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.982
sirA
SirA protein/redox protein, regulator of disulfide bond formation; COG:O;COG0425; Belongs to the sulfur carrier protein TusA family.
   
 0.972
nfuA
Putative DNA uptake protein, cytoplasmic protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
 
 0.968
HAPS_0052
HTH-type transcriptional regulator, BadM/Rrf2 family; COG:K;COG1959.
 
  
 0.964
moeB
Molybdopterin biosynthesis protein MoeB; COG:H;COG0476.
   
 0.956
mccB
UBA/THIF-type NAD/FAD binding protein, bacteriocin biosynthesis protein.
   
 0.956
Your Current Organism:
Glaesserella parasuis
NCBI taxonomy Id: 557723
Other names: G. parasuis SH0165, Glaesserella parasuis SH0165, Haemophilus parasuis SH0165
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.