STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (314 aa)    
Predicted Functional Partners:
gltA
Type II citrate synthase; COG:C;COG0372; Belongs to the citrate synthase family.
  
 0.987
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.982
pckA
Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
  
 
 0.968
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family.
     
 0.964
sfcA
Malic enzyme; COG:C;COG0281.
  
 0.963
aspC
Aromatic amino acid aminotransferase; COG:E;COG1448.
   
 0.938
frdB
Fumarate reductase (anaerobic), Fe-S subunit; COG:C;COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 
 0.906
frdA
Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; COG:C;COG1053.
 
 
 0.892
icd
Isocitrate dehydrogenase (NADP(+)); COG:C;COG0538.
  
 
 0.889
gltB
Glutamate synthase (ferredoxin), subunit alpha; COG:E;COG0069.
  
 
 0.886
Your Current Organism:
Glaesserella parasuis
NCBI taxonomy Id: 557723
Other names: G. parasuis SH0165, Glaesserella parasuis SH0165, Haemophilus parasuis SH0165
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