node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carA | carB | HAPS_1892 | HAPS_1893 | Carbamoyl phosphate synthase small subunit; COG:EF;COG0505; Belongs to the CarA family. | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | 0.999 |
carA | pryE | HAPS_1892 | HAPS_0826 | Carbamoyl phosphate synthase small subunit; COG:EF;COG0505; Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.884 |
carA | pyrD | HAPS_1892 | HAPS_2040 | Carbamoyl phosphate synthase small subunit; COG:EF;COG0505; Belongs to the CarA family. | Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.925 |
carA | pyrF | HAPS_1892 | HAPS_0456 | Carbamoyl phosphate synthase small subunit; COG:EF;COG0505; Belongs to the CarA family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.886 |
carA | uraA | HAPS_1892 | HAPS_1655 | Carbamoyl phosphate synthase small subunit; COG:EF;COG0505; Belongs to the CarA family. | Uracil permease; COG:F;COG2233. | 0.815 |
carB | carA | HAPS_1893 | HAPS_1892 | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | Carbamoyl phosphate synthase small subunit; COG:EF;COG0505; Belongs to the CarA family. | 0.999 |
carB | guaA | HAPS_1893 | HAPS_0297 | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.723 |
carB | guaB | HAPS_1893 | HAPS_0294 | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | Inositol-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.507 |
carB | pryE | HAPS_1893 | HAPS_0826 | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.909 |
carB | purA | HAPS_1893 | HAPS_2160 | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.594 |
carB | pyrD | HAPS_1893 | HAPS_2040 | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.931 |
carB | pyrF | HAPS_1893 | HAPS_0456 | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.902 |
carB | uraA | HAPS_1893 | HAPS_1655 | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | Uracil permease; COG:F;COG2233. | 0.782 |
guaA | carB | HAPS_0297 | HAPS_1893 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Carbamoyl phosphate synthase large subunit; COG:EF;COG0458; Belongs to the CarB family. | 0.723 |
guaA | guaB | HAPS_0297 | HAPS_0294 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Inositol-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | pheT | HAPS_0297 | HAPS_0692 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | phenylalanyl-tRNA synthetase subunit beta; COG:J;COG0072; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.884 |
guaA | prsA | HAPS_0297 | HAPS_2039 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.697 |
guaA | pryE | HAPS_0297 | HAPS_0826 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.633 |
guaA | purA | HAPS_0297 | HAPS_2160 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.903 |
guaA | pyrD | HAPS_0297 | HAPS_2040 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.589 |