STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
norVBeta-lactamase domain protein; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (503 aa)    
Predicted Functional Partners:
norW
FAD-dependent pyridine nucleotide-disulphide oxidoreductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
 
 0.999
PC1_2730
TIGRFAM: nitrite reductase [NAD(P)H], large subunit; nitrite reductase [NAD(P)H], small subunit; PFAM: nitrite and sulphite reductase 4Fe-4S region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit.
  
 
 0.920
PC1_3869
TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: nitrite and sulphite reductase 4Fe-4S region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: eca:ECA4079 nitrite reductase [NAD(P)H] large subunit.
 
 
 0.916
norR
Transcriptional regulator, NifA subfamily, Fis Family; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.
 
   
 0.784
hcp
Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
 
   
 0.780
PC1_1838
Ferroxidase; Iron-storage protein.
 
  
 0.756
PC1_0698
TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: eca:ECA0824 pyruvate-flavodoxin oxidoreductase.
 
  
 0.696
PC1_1354
PFAM: Protein of unknown function DUF1971; KEGG: eca:ECA1474 hypothetical protein.
 
  
 0.661
ytfE
Protein of unknown function DUF542 ScdA domain protein; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions.
  
  
 0.642
PC1_1015
PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: eca:ECA1117 peroxidase.
  
  
 0.631
Your Current Organism:
Pectobacterium carotovorum
NCBI taxonomy Id: 561230
Other names: P. carotovorum subsp. carotovorum PC1, Pectobacterium carotovorum subsp. carotovorum PC1, Pectobacterium carotovorum subsp. carotovorum str. PC1, Pectobacterium carotovorum subsp. carotovorum strain PC1
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