node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PC1_0177 | PC1_0578 | PC1_0177 | PC1_0578 | O-succinylhomoserine (thiol)-lyase; KEGG: eca:ECA4252 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; condensation domain protein; KEGG: rso:RS05859 peptide synthetase protein; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.400 |
PC1_0177 | sufS | PC1_0177 | PC1_2446 | O-succinylhomoserine (thiol)-lyase; KEGG: eca:ECA4252 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | Cysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. | 0.900 |
PC1_0578 | PC1_0177 | PC1_0578 | PC1_0177 | TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; condensation domain protein; KEGG: rso:RS05859 peptide synthetase protein; Belongs to the ATP-dependent AMP-binding enzyme family. | O-succinylhomoserine (thiol)-lyase; KEGG: eca:ECA4252 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.400 |
PC1_0578 | PC1_1717 | PC1_0578 | PC1_1717 | TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; condensation domain protein; KEGG: rso:RS05859 peptide synthetase protein; Belongs to the ATP-dependent AMP-binding enzyme family. | TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: eca:ECA2649 thioredoxin reductase. | 0.407 |
PC1_0578 | PC1_3030 | PC1_0578 | PC1_3030 | TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; condensation domain protein; KEGG: rso:RS05859 peptide synthetase protein; Belongs to the ATP-dependent AMP-binding enzyme family. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.460 |
PC1_0578 | sufS | PC1_0578 | PC1_2446 | TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; condensation domain protein; KEGG: rso:RS05859 peptide synthetase protein; Belongs to the ATP-dependent AMP-binding enzyme family. | Cysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. | 0.608 |
PC1_0924 | PC1_2447 | PC1_0924 | PC1_2447 | TIGRFAM: cysteine desulfurase, sulfur acceptor subunit CsdE; PFAM: Fe-S metabolism associated SufE; KEGG: eca:ECA1011 putative Fe-S metabolism associated protein. | TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: eca:ECA1862 cysteine desulfurase activator complex subunit SufD. | 0.668 |
PC1_0924 | PC1_2448 | PC1_0924 | PC1_2448 | TIGRFAM: cysteine desulfurase, sulfur acceptor subunit CsdE; PFAM: Fe-S metabolism associated SufE; KEGG: eca:ECA1011 putative Fe-S metabolism associated protein. | FeS assembly ATPase SufC; KEGG: eca:ECA1861 cysteine desulfurase ATPase component; TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase. | 0.695 |
PC1_0924 | PC1_2449 | PC1_0924 | PC1_2449 | TIGRFAM: cysteine desulfurase, sulfur acceptor subunit CsdE; PFAM: Fe-S metabolism associated SufE; KEGG: eca:ECA1011 putative Fe-S metabolism associated protein. | TIGRFAM: FeS assembly protein SufB; PFAM: SufBD protein; KEGG: eca:ECA1860 cysteine desulfurase activator complex subunit SufB. | 0.774 |
PC1_0924 | sufS | PC1_0924 | PC1_2446 | TIGRFAM: cysteine desulfurase, sulfur acceptor subunit CsdE; PFAM: Fe-S metabolism associated SufE; KEGG: eca:ECA1011 putative Fe-S metabolism associated protein. | Cysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. | 0.873 |
PC1_1717 | PC1_0578 | PC1_1717 | PC1_0578 | TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: eca:ECA2649 thioredoxin reductase. | TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; condensation domain protein; KEGG: rso:RS05859 peptide synthetase protein; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.407 |
PC1_1717 | PC1_2448 | PC1_1717 | PC1_2448 | TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: eca:ECA2649 thioredoxin reductase. | FeS assembly ATPase SufC; KEGG: eca:ECA1861 cysteine desulfurase ATPase component; TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase. | 0.450 |
PC1_1717 | PC1_3030 | PC1_1717 | PC1_3030 | TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: eca:ECA2649 thioredoxin reductase. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.506 |
PC1_1717 | sufS | PC1_1717 | PC1_2446 | TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: eca:ECA2649 thioredoxin reductase. | Cysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. | 0.925 |
PC1_2447 | PC1_0924 | PC1_2447 | PC1_0924 | TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: eca:ECA1862 cysteine desulfurase activator complex subunit SufD. | TIGRFAM: cysteine desulfurase, sulfur acceptor subunit CsdE; PFAM: Fe-S metabolism associated SufE; KEGG: eca:ECA1011 putative Fe-S metabolism associated protein. | 0.668 |
PC1_2447 | PC1_2448 | PC1_2447 | PC1_2448 | TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: eca:ECA1862 cysteine desulfurase activator complex subunit SufD. | FeS assembly ATPase SufC; KEGG: eca:ECA1861 cysteine desulfurase ATPase component; TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase. | 0.998 |
PC1_2447 | PC1_2449 | PC1_2447 | PC1_2449 | TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: eca:ECA1862 cysteine desulfurase activator complex subunit SufD. | TIGRFAM: FeS assembly protein SufB; PFAM: SufBD protein; KEGG: eca:ECA1860 cysteine desulfurase activator complex subunit SufB. | 0.989 |
PC1_2447 | PC1_2450 | PC1_2447 | PC1_2450 | TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: eca:ECA1862 cysteine desulfurase activator complex subunit SufD. | TIGRFAM: FeS assembly scaffold SufA; iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein; KEGG: eca:ECA1859 iron-sulfur cluster assembly scaffold protein; Belongs to the HesB/IscA family. | 0.819 |
PC1_2447 | PC1_3030 | PC1_2447 | PC1_3030 | TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: eca:ECA1862 cysteine desulfurase activator complex subunit SufD. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.752 |
PC1_2447 | sufE | PC1_2447 | PC1_2445 | TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: eca:ECA1862 cysteine desulfurase activator complex subunit SufD. | Fe-S metabolism associated SufE; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. | 0.918 |