node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PC1_1011 | PC1_1464 | PC1_1011 | PC1_1464 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | 0.900 |
PC1_1011 | PC1_1535 | PC1_1011 | PC1_1535 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. | 0.932 |
PC1_1011 | PC1_1851 | PC1_1011 | PC1_1851 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | PFAM: GAF domain protein; SMART: GAF domain protein; KEGG: eca:ECA2461 hypothetical protein. | 0.900 |
PC1_1011 | PC1_3504 | PC1_1011 | PC1_3504 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | Aromatic-amino-acid transaminase; PFAM: aminotransferase class I and II; KEGG: eca:ECA3670 aromatic amino acid aminotransferase. | 0.902 |
PC1_1011 | PC1_3775 | PC1_1011 | PC1_3775 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.915 |
PC1_1011 | metE | PC1_1011 | PC1_4073 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.900 |
PC1_1011 | metK | PC1_1011 | PC1_3707 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.963 |
PC1_1464 | PC1_1011 | PC1_1464 | PC1_1011 | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | 0.900 |
PC1_1464 | PC1_1535 | PC1_1464 | PC1_1535 | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. | 0.912 |
PC1_1464 | PC1_1851 | PC1_1464 | PC1_1851 | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | PFAM: GAF domain protein; SMART: GAF domain protein; KEGG: eca:ECA2461 hypothetical protein. | 0.900 |
PC1_1464 | PC1_3504 | PC1_1464 | PC1_3504 | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | Aromatic-amino-acid transaminase; PFAM: aminotransferase class I and II; KEGG: eca:ECA3670 aromatic amino acid aminotransferase. | 0.902 |
PC1_1464 | PC1_3775 | PC1_1464 | PC1_3775 | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.915 |
PC1_1464 | metE | PC1_1464 | PC1_4073 | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.904 |
PC1_1464 | metK | PC1_1464 | PC1_3707 | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.963 |
PC1_1535 | PC1_1011 | PC1_1535 | PC1_1011 | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | 0.932 |
PC1_1535 | PC1_1464 | PC1_1535 | PC1_1464 | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. | 2-hydroxypropyl-CoM lyase; PFAM: Methionine synthase vitamin-B12 independent; KEGG: eta:ETA_10400 methionine synthase. | 0.912 |
PC1_1535 | PC1_1851 | PC1_1535 | PC1_1851 | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. | PFAM: GAF domain protein; SMART: GAF domain protein; KEGG: eca:ECA2461 hypothetical protein. | 0.908 |
PC1_1535 | PC1_3504 | PC1_1535 | PC1_3504 | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. | Aromatic-amino-acid transaminase; PFAM: aminotransferase class I and II; KEGG: eca:ECA3670 aromatic amino acid aminotransferase. | 0.905 |
PC1_1535 | PC1_3775 | PC1_1535 | PC1_3775 | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.921 |
PC1_1535 | metE | PC1_1535 | PC1_4073 | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.912 |