STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Saut_1010COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948:IPR020053; KEGG: pin:Ping_1777 putative aminopeptidase 2; PFAM: peptidase M18 aminopeptidase I; PRIAM: Aspartyl aminopeptidase; SPTR: A3JG81 M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). (420 aa)    
Predicted Functional Partners:
Saut_1011
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR004358:IPR003594:IPR003661:IPR005467; KEGG: tdn:Suden_0914 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: A9A3C3 Sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
       0.787
Saut_1009
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR001633:IPR000160:IPR013656:IPR000700:IPR 000014; KEGG: sun:SUN_1481 hypothetical protein; PFAM: EAL domain protein; GGDEF domain containing protein; PAS fold-4 domain protein; SMART: EAL domain protein; GGDEF domain containing protein; SPTR: A3LI29 Putative uncharacterized protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclas [...]
       0.762
Saut_1008
COGs: COG0587 DNA polymerase III alpha subunit; InterPro IPR011708:IPR004013:IPR004365:IPR003141:IPR 004805; KEGG: tdn:Suden_0910 DNA polymerase III subunit alpha; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein; SPTR: P56157 DNA polymerase III subunit alpha; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; DNA-directed DNA poly [...]
       0.712
Saut_1007
RimK domain protein ATP-grasp; COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR013651:IPR003583:IPR011761; KEGG: sun:SUN_1053 hypothetical protein; PFAM: RimK domain protein ATP-grasp; SMART: Helix-hairpin-helix DNA-binding class 1; SPTR: Q8ZXK1 Ribosomal protein S6 modification protein (RimK); PFAM: RimK-like ATP-grasp domain.
       0.632
Saut_1012
Hypothetical protein.
       0.596
efp
Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
       0.555
tgt
tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...]
       0.406
Your Current Organism:
Sulfurimonas autotrophica
NCBI taxonomy Id: 563040
Other names: S. autotrophica DSM 16294, Sulfurimonas autotrophica DSM 16294, Sulfurimonas autotrophica OK10, Sulfurimonas autotrophica str. DSM 16294, Sulfurimonas autotrophica strain DSM 16294
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