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BHWA1_00223 protein (Brachyspira hyodysenteriae) - STRING interaction network
"BHWA1_00223" - Chaperone protein DnaJ in Brachyspira hyodysenteriae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BHWA1_00223Chaperone protein DnaJ (96 aa)    
Predicted Functional Partners:
dnaK
Molecular chaperone DnaK; Acts as a chaperone (622 aa)
 
  0.978
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent [...] (200 aa)
 
  0.962
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (376 aa)
 
 
0.847
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (543 aa)
   
  0.792
pqqL
Zn-dependent peptidase (421 aa)
     
    0.720
hlyB
Hemolysin B (828 aa)
   
 
  0.717
clpB
ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE (859 aa)
   
 
  0.717
BHWA1_00222
Hypothetical protein (230 aa)
              0.715
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (698 aa)
     
  0.710
BHWA1_00648
Regulatory protein, MerR (138 aa)
   
 
  0.686
Your Current Organism:
Brachyspira hyodysenteriae
NCBI taxonomy Id: 565034
Other names: B. hyodysenteriae, B. hyodysenteriae WA1, Brachyspira hyodysenteriae, Brachyspira hyodysenteriae WA1, Brachyspira hyodysenteriae str. WA1, Brachyspira hyodysenteriae strain WA1, Serpula hyodysenteriae, Serpulina hyodysenteriae, Treponema hyodysenteriae
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