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BHWA1_00464 protein (Brachyspira hyodysenteriae) - STRING interaction network
"BHWA1_00464" - 5-methyltetrahydrofolate--homocysteine methyltransferase in Brachyspira hyodysenteriae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BHWA1_004645-methyltetrahydrofolate--homocysteine methyltransferase (873 aa)    
Predicted Functional Partners:
BHWA1_00465
5-methyltetrahydrofolate--homocysteine methyltransferase (270 aa)
  0.999
metF
Methylenetetrahydrofolate reductase (308 aa)
 
  0.998
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (394 aa)
   
 
  0.991
BHWA1_01511
O-acetylhomoserine/O-acetylserine sulfhydrylase (431 aa)
       
  0.990
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (475 aa)
   
 
  0.982
fhs
Formate--tetrahydrofolate ligase (553 aa)
   
 
  0.974
malY
Bifunctional PLP-dependent protein/beta-cystathionase and maltose regulon repressor (399 aa)
         
  0.970
cysK
Cysteine synthase A (304 aa)
   
 
  0.965
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (166 aa)
   
 
  0.915
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (651 aa)
     
 
  0.915
Your Current Organism:
Brachyspira hyodysenteriae
NCBI taxonomy Id: 565034
Other names: B. hyodysenteriae, B. hyodysenteriae WA1, Brachyspira hyodysenteriae, Brachyspira hyodysenteriae WA1, Brachyspira hyodysenteriae str. WA1, Brachyspira hyodysenteriae strain WA1, Serpula hyodysenteriae, Serpulina hyodysenteriae, Treponema hyodysenteriae
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