STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LMJF_29_2800Putative inosine-adenosine-guanosine-nucleoside hydrolase. (333 aa)    
Predicted Functional Partners:
LMJF_29_0867
Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
  
 
 0.923
APRT
Adenine phosphoribosyltransferase.
    
 0.921
LMJF_34_3600
Adenosine kinase-like protein.
  
 
 0.918
LMJF_30_0890
Adenosine kinase-like protein.
  
 
 0.918
LMJF_30_0880
Putative adenosine kinase.
  
 
 0.918
HGPRT
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.909
AAH
Adenine aminohydrolase.
  
 
 0.906
SIR2rp3
NAD-dependent protein deacylase SIR2rp3; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.905
SIR2rp1
NAD-dependent protein deacetylase SIR2rp1; NAD-dependent deacetylase, which probably acts as a regulator of gene expression believed to help form modified chromatin structures on the genes it regulates; Belongs to the sirtuin family. Class I subfamily.
  
 
 0.902
NH
Nonspecific nucleoside hydrolase.
  
   
 0.437
Your Current Organism:
Leishmania major
NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania tropica major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.