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PTR1 protein (Leishmania major) - STRING interaction network
"PTR1" - Pteridine reductase 1 in Leishmania major
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PTR1Pteridine reductase 1; Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX); Belongs to the short-chain dehydrogenases/reductases (SDR) family (288 aa)    
Predicted Functional Partners:
DHFR-TS
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity); In the N-terminal section; belongs to the dihydrofolate reductase family (520 aa)
   
   
  0.916
SHMT-L
Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family (474 aa)
         
  0.862
LmjF.33.2720
3-oxoacyl-acyl carrier protein synthase ii, putative.[Source-GeneDB;Acc-LmjF.33.2720]; Belongs to the beta-ketoacyl-ACP synthases family (459 aa)
 
 
  0.861
SHMT-S
Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family (465 aa)
         
  0.857
ACP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis (150 aa)
   
 
  0.846
LmjF.31.2970
acetyl-CoA carboxylase, putative.[Source-GeneDB;Acc-LmjF.31.2970] (2168 aa)
   
 
  0.782
QDPR
Quinonoid dihydropteridine reductase.[Source-GeneDB;Acc-LmjF.34.4510] (229 aa)
           
  0.770
TRYR
Trypanothione reductase.[Source-GeneDB;Acc-LmjF.05.0350]; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family (491 aa)
     
 
  0.748
GCVP
Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine (972 aa)
         
  0.729
QDPR-1
Quinonoid dihydropteridine reductase.[Source-GeneDB;Acc-LmjF.34.4330] (229 aa)
           
  0.721
Your Current Organism:
Leishmania major
NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania major, Leishmania tropica major
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