node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SYN_00176 | SYN_00461 | SYN_00176 | SYN_00461 | Methylenetetrahydrofolate reductase. | Glutamate formiminotransferase. | 0.922 |
SYN_00176 | SYN_01410 | SYN_00176 | SYN_01410 | Methylenetetrahydrofolate reductase. | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.482 |
SYN_00176 | SYN_02703 | SYN_00176 | SYN_02703 | Methylenetetrahydrofolate reductase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.997 |
SYN_00176 | carB | SYN_00176 | SYN_01625 | Methylenetetrahydrofolate reductase. | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | 0.618 |
SYN_00176 | fhs | SYN_00176 | SYN_02008 | Methylenetetrahydrofolate reductase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.958 |
SYN_00176 | folD | SYN_00176 | SYN_02873 | Methylenetetrahydrofolate reductase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.954 |
SYN_00176 | glyA | SYN_00176 | SYN_02367 | Methylenetetrahydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
SYN_00176 | guaA | SYN_00176 | SYN_01626 | Methylenetetrahydrofolate reductase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.612 |
SYN_00176 | purH | SYN_00176 | SYN_02440 | Methylenetetrahydrofolate reductase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Bifunctional. | 0.937 |
SYN_00176 | purN | SYN_00176 | SYN_00888 | Methylenetetrahydrofolate reductase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.947 |
SYN_00461 | SYN_00176 | SYN_00461 | SYN_00176 | Glutamate formiminotransferase. | Methylenetetrahydrofolate reductase. | 0.922 |
SYN_00461 | SYN_02703 | SYN_00461 | SYN_02703 | Glutamate formiminotransferase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.912 |
SYN_00461 | fhs | SYN_00461 | SYN_02008 | Glutamate formiminotransferase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.912 |
SYN_00461 | folD | SYN_00461 | SYN_02873 | Glutamate formiminotransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.907 |
SYN_00461 | glyA | SYN_00461 | SYN_02367 | Glutamate formiminotransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
SYN_00461 | purH | SYN_00461 | SYN_02440 | Glutamate formiminotransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Bifunctional. | 0.900 |
SYN_00461 | purN | SYN_00461 | SYN_00888 | Glutamate formiminotransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
SYN_01410 | SYN_00176 | SYN_01410 | SYN_00176 | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Methylenetetrahydrofolate reductase. | 0.482 |
SYN_01410 | SYN_02703 | SYN_01410 | SYN_02703 | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.412 |
SYN_01410 | fhs | SYN_01410 | SYN_02008 | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.889 |