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hisF protein (Acidaminococcus intestini) - STRING interaction network
"hisF" - Imidazole glycerol phosphate synthase subunit HisF in Acidaminococcus intestini
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Predicted Interactions
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textmining
co-expression
protein homology
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hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (254 aa)    
Predicted Functional Partners:
hisIE
Histidine biosynthesis bifunctional protein HisIE; COG0140; In the N-terminal section; belongs to the PRA-CH family (222 aa)
   
  0.999
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (204 aa)
  0.999
Acin_0892
Imidazoleglycerol-phosphate dehydratase; COG0131; Belongs to the imidazoleglycerol-phosphate dehydratase family (113 aa)
  0.999
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106 (245 aa)
 
 
0.998
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (448 aa)
 
  0.997
Acin_0891
Imidazoleglycerol-phosphate dehydratase; COG0131; Belongs to the imidazoleglycerol-phosphate dehydratase family (73 aa)
 
  0.997
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Short subfamily (215 aa)
 
 
  0.992
Acin_0890
annotation not available (384 aa)
 
  0.989
Acin_0994
annotation not available (173 aa)
 
 
  0.910
trpE
Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (534 aa)
 
   
  0.874
Your Current Organism:
Acidaminococcus intestini
NCBI taxonomy Id: 568816
Other names: A. intestini RyC-MR95, Acidaminococcus intestini, Acidaminococcus intestini RyC-MR95, Acidaminococcus intestini strain RyC-MR95
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